Can we assess the glycation of lens proteins in diabetes with non-invasive methods?

JanSkrha2015Dr. Jan Škrha will hightlight the question concerning the assessment of the glycation of lens proteins in diabetes with non-invasive methods, at the Glycation World Congress 2016.

The accumulation of advanced glycation endproducts in the lens reflects total glycation rate in the human body. While this phenomenon has been known for many years, any quick and easy measurement of this lens glycation was missing. Recently, a new confocal biomicroscope non-invasively measuring lens autofluorescence and reflecting some AGEs accumulation has been developed. Our pilot study including 180 subjects compared lens autofluorescence and skin autofluorescence assessed by AGE-Reader. Both measurements were significantly higher in patients with diabetes and a significant relationship between lens and skin autofluorescence was observed. Lens autofluorescence could be a robust marker of long-term diabetes control predicting future complication risks. However, confirmation of such hypothesis will need other and long-term clinical studies.