The role of hemoglobin derived heme in the pathogenesis of vascular disorders

ballaDr. György Balla is working at the University of Debrecen in Hungary. During Glycation & Maillard Reaction Congress which will be held in Budapest on May 26-27, 2016 he will give a presentation about the role of hemoglobin derived heme in the pathogenesis of vascular disorders.

According to dr. Balla, in the pathogenesis of several vascular disorder modified proteins and lipids generated by reactive oxygen species accumulate in the vessel wall resulted in atherosclerosis, calcification, neovascularization. Since transition metals are also accumulating in these pathologies, generating continuous free radical stress. The team of dr. Balla suggested that the source of iron is heme derived from modified hemoglobin. Using in vitro cell culture models and human vessel samples, they proved, that heme is an efficient free radical catalyst, toxic for cell membranes and lipoproteins leading to vessel injury.


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